What is the immediate action when a patient shows signs of opioid overdose with respiratory depression?

• A. Wait to see if symptoms improve.
• B. Notify the nurse/physician and prepare to administer naloxone per order, with continuous monitoring.
• C. Administer a benzodiazepine.
• D. Ignore and monitor vitals only.

Answer: (A)

In opioid overdose with respiratory depression, the priority is rapid reversal of the opioid effects and ensuring the patient’s breathing is supported. Immediately notify the nurse or physician and prepare to administer naloxone per order, while continuously monitoring breathing, oxygenation, and vital signs. Naloxone acts quickly to displace opioids from receptors and restore respiration, but it must be given according to protocol to ensure safety. While this is happening, don’t delay treatment or rely on observation alone; provide airway support and keep monitoring closely. Avoid giving benzodiazepines, as they can further depress respiration, and never ignore the patient.